二甲双胍联合地屈孕酮治疗多囊卵巢综合征的临床效果(1)
[摘要]目的 探討二甲双胍辅助治疗多囊卵巢综合征(PCOS)患者的临床效果。方法 选取2015年3月～2017年6月我院治疗的30例PCOS患者作为研究对象，按照随机数字表法分为对照组和研究组，每组各15例。对照组给予地屈孕酮治疗，研究组在对照组基础上加二甲双胍辅助治疗。比较两组临床疗效、肿瘤坏死因子-α(TNF-α)、胰岛素抵抗指数(HOMA-IR)、血清雌二醇(E2)、卵泡刺激素(FSH)、睾酮(T)、促黄体生成素(LH)水平及不良反应发生情况。结果 研究组临床总有效率(93.33%)高于对照组(60.00%)，差异有统计学意义(P<0.05)。两组干预前HOMA-IR、TNF-α、LH、FSH、T、E2水平比较，差异无统计学意义(P>0.05)，干预后两组HOMA-IR、TNF-α、LH、FSH、T、E2水平低于干预前，且研究组低于对照组，差异有统计学意义(P<0.05)。研究组不良反应总发生率(13.33%)与对照组(20.00%)比较，差异无统计学意义(P>0.05)。结论 二甲双胍辅助地屈孕酮治疗PCOS效果显著，可显著改善患者子宫内膜胰岛素抵抗、炎症状态及内分泌代谢情况。
[关键词]多囊卵巢综合征;胰岛素抵抗;二甲双胍;地屈孕酮;内分泌代谢
[中图分类号] R711.75 [文献标识码] A [文章编号] 1674-4721(2020)2(b)-0137-03
[Abstract] Objective To investigate the clinical effect of Metformin as adjuvant therapy for treatment of patients with polycystic ovary syndrome (PCOS). Methods Thirty patients with PCOS who came to our hospital from March 2015 to June 2017 were selected as subjects of study. They were divided into control group and study group according to the random number table method， 15 cases in each group. The control group was treated with Dydrogesterone， while the study group was added with Metformin besides Dydrogesterone. The clinical efficacy， tumor necrosis factor-α (TNF-α)， homeostasis model assessment-insulin resistance (HOMA-IR)， serum estradiol (E2)， follicle stimulating hormone (FSH)， testosterone (T)， luteinizing hormone (LH)， and the occurrence of adverse reactions were compared between the two groups. Results The clinical effective rate of the study group was 93.33%， higher than that of the control group accounting for 60.00%，the difference was statistically significant (P<0.05). There were no significant differences in HOMA-IR， TNF-α， LH， FSH， T and E2 levels between the two groups before intervention (P>0.05). After intervention， HOMA-IR， TNF-α， LH， FSH， T， and E2 level were lower than those before the intervention， and those indexes in study group were lower than those of the control group，the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the study group (13.33%) and the control group (20.00%) (P>0.05). Conclusion Metformin is effective in the treatment of PCOS with Dexamethasone， which can improve IR， inflammatory status and endocrine metabolism in patients.
[Key words] Polycystic ovary syndrome; Insulin resistance; Metformin; Dydrogesterone; Endocrine metabolism, 百拇医药(钟秀嫦)
[关键词]多囊卵巢综合征;胰岛素抵抗;二甲双胍;地屈孕酮;内分泌代谢
[中图分类号] R711.75 [文献标识码] A [文章编号] 1674-4721(2020)2(b)-0137-03
[Abstract] Objective To investigate the clinical effect of Metformin as adjuvant therapy for treatment of patients with polycystic ovary syndrome (PCOS). Methods Thirty patients with PCOS who came to our hospital from March 2015 to June 2017 were selected as subjects of study. They were divided into control group and study group according to the random number table method， 15 cases in each group. The control group was treated with Dydrogesterone， while the study group was added with Metformin besides Dydrogesterone. The clinical efficacy， tumor necrosis factor-α (TNF-α)， homeostasis model assessment-insulin resistance (HOMA-IR)， serum estradiol (E2)， follicle stimulating hormone (FSH)， testosterone (T)， luteinizing hormone (LH)， and the occurrence of adverse reactions were compared between the two groups. Results The clinical effective rate of the study group was 93.33%， higher than that of the control group accounting for 60.00%，the difference was statistically significant (P<0.05). There were no significant differences in HOMA-IR， TNF-α， LH， FSH， T and E2 levels between the two groups before intervention (P>0.05). After intervention， HOMA-IR， TNF-α， LH， FSH， T， and E2 level were lower than those before the intervention， and those indexes in study group were lower than those of the control group，the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the study group (13.33%) and the control group (20.00%) (P>0.05). Conclusion Metformin is effective in the treatment of PCOS with Dexamethasone， which can improve IR， inflammatory status and endocrine metabolism in patients.
[Key words] Polycystic ovary syndrome; Insulin resistance; Metformin; Dydrogesterone; Endocrine metabolism, 百拇医药(钟秀嫦)
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